| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/7/2008 | ChA | Buchholz | Demoted to reserve roster | | | Before |
| 4/7/2008 | ChA | Catalanotto | Demoted to reserve roster | | | Before |
| 4/7/2008 | ChA | Donnelly | Demoted to reserve roster | | | Before |
| 4/7/2008 | ChA | Maxwell | Demoted to reserve roster | | | Before |
| 4/7/2008 | ChA | Mench | Demoted to reserve roster | | | Before |
| 4/7/2008 | ChA | Petit | Demoted to reserve roster | | | Before |
| 4/7/2008 | ChA | Valentin | Demoted to reserve roster | | | Before |
| 4/7/2008 | ChA | Wood | Demoted to reserve roster | | | Before |
| 4/7/2008 | CIN | Carpenter | Demoted to reserve roster | | | Before |
| 4/7/2008 | CIN | Chavez | Demoted to reserve roster | | | Before |
| 4/7/2008 | CIN | Chavez | Promoted to active roster | | | Before |
| 4/7/2008 | CIN | Dotel | Demoted to reserve roster | | | Before |
| 4/7/2008 | CIN | Eveland | Demoted to reserve roster | | | Before |
| 4/7/2008 | CIN | Fontenot | Demoted to reserve roster | | | Before |
| 4/7/2008 | CIN | Francisco | Demoted to reserve roster | | | Before |
| 4/7/2008 | CIN | Gabbard | Demoted to reserve roster | | | Before |
| 4/7/2008 | CIN | Laffey | Demoted to reserve roster | | | Before |
| 4/7/2008 | CIN | Nippert | Demoted to reserve roster | | | Before |
| 4/7/2008 | KC | Abreu | Demoted to reserve roster | | | Before |
| 4/7/2008 | KC | Andino | Demoted to reserve roster | | | Before |
| 4/7/2008 | KC | Cruz | Demoted to reserve roster | | | Before |
| 4/7/2008 | KC | Duncan | Demoted to reserve roster | | | Before |
| 4/7/2008 | KC | Gonzalez | Demoted to reserve roster | | | Before |
| 4/7/2008 | KC | Guzman | Demoted to reserve roster | | | Before |
| 4/7/2008 | KC | Jones | Demoted to reserve roster | | | Before |
| 4/7/2008 | KC | Pelfrey | Demoted to reserve roster | | | Before |
| 4/7/2008 | SD | Abercrombie | Demoted to reserve roster | | | Before |
| 4/7/2008 | SD | Buscher | Demoted to reserve roster | | | Before |
| 4/7/2008 | SD | Cedeno | Demoted to reserve roster | | | Before |
| 4/7/2008 | SD | Cruz | Demoted to reserve roster | | | Before |
| 4/7/2008 | SD | Duchscherer | Demoted to reserve roster | | | Before |
| 4/7/2008 | SD | Duffy | Demoted to reserve roster | | | Before |
| 4/7/2008 | SD | Gonzalez | Demoted to reserve roster | | | Before |
| 4/7/2008 | SD | Zobrist | Demoted to reserve roster | | | Before |
| 4/23/2008 | CIN | Chavez | Demoted to reserve roster | | | Before |
| 4/23/2008 | CIN | Dotel | Promoted to active roster | | | Before |
| 4/23/2008 | CIN | Gabbard | Promoted to active roster | | | Before |
| 4/23/2008 | CIN | Thompson | Demoted to reserve roster | | | Before |
| 4/23/2008 | Mil | Gomez | Demoted to reserve roster | | | Before |
| 4/23/2008 | Mil | Izturis | Promoted to active roster | | | Before |
| 4/23/2008 | Mil | Salazar | Promoted to active roster | | | Before |
| 4/23/2008 | Mil | Schumaker | Demoted to reserve roster | | | Before |
| 5/1/2008 | ChA | Diaz | Demoted to reserve roster | | | Before |
| 5/1/2008 | ChA | Mench | Promoted to active roster | | | Before |
| 5/1/2008 | ChA | Soto | Demoted to reserve roster | | | Before |
| 5/1/2008 | ChA | Valentin | Promoted to active roster | | | Before |
| 5/1/2008 | Mil | Buck | Demoted to reserve roster | | | Before |
| 5/1/2008 | Mil | Feliz | Demoted to reserve roster | | | Before |
| 5/1/2008 | Mil | Feliz | Promoted to active roster | | | Before |
| 5/1/2008 | Mil | Gomez | Promoted to active roster | | | Before |
| 5/3/2008 | NYY | Humber | Promoted to active roster | | | Before |
| 5/3/2008 | NYY | Ramirez | Demoted to reserve roster | | | Before |
| 5/9/2008 | KC | Cruz | Promoted to active roster | | | Before |
| 5/9/2008 | KC | McBride | Demoted to reserve roster | | | Before |
| 5/9/2008 | Mil | Buck | Promoted to active roster | | | Before |
| 5/9/2008 | Mil | Hill | Demoted to reserve roster | | | Before |
| 5/9/2008 | Mil | Redding | Promoted to active roster | | | Before |
| 5/9/2008 | Mil | Salazar | Demoted to reserve roster | | | Before |
| 5/9/2008 | NYY | Botts | Promoted to active roster | | | Before |
| 5/9/2008 | NYY | Davis | Demoted to reserve roster | | | Before |
| 5/9/2008 | NYY | Giambi | Demoted to reserve roster | | | Before |
| 5/9/2008 | NYY | Giambi | Promoted to active roster | | | Before |
| 5/9/2008 | NYY | Humber | Demoted to reserve roster | | | Before |
| 5/9/2008 | NYY | Taveras | Promoted to active roster | | | Before |
| 5/11/2008 | LAA | Albers | Demoted to reserve roster | | | Before |
| 5/11/2008 | LAA | Hughes | Promoted to active roster | | | Before |
| 5/11/2008 | Tex | Garza | Promoted to active roster | | | Before |
| 5/11/2008 | Tex | Gwynn | Promoted to active roster | | | Before |
| 5/11/2008 | Tex | Lester | Promoted to active roster | | | Before |
| 5/11/2008 | Tex | Murphy | Demoted to reserve roster | | | Before |
| 5/11/2008 | Tex | Rogers | Demoted to reserve roster | | | Before |
| 5/11/2008 | Tex | Sanchez | Demoted to reserve roster | | | Before |
| 6/30/2008 | Atl | Callaspo | Promoted to active roster | | | Before |
| 6/30/2008 | Atl | Ellsbury | Demoted to reserve roster | | | Before |
| 6/30/2008 | Atl | Gonzalez,Ed | Demoted to reserve roster | | | Before |
| 6/30/2008 | Atl | Ojeda | Demoted to reserve roster | | | Before |
| 6/30/2008 | Atl | Sonnanstine | Promoted to active roster | | | Before |
| 6/30/2008 | Atl | Valentin | Promoted to active roster | | | Before |
| 6/30/2008 | CIN | Castillo | Demoted to reserve roster | | | Before |
| 6/30/2008 | CIN | Fontenot | Promoted to active roster | | | Before |
| 6/30/2008 | CIN | Laffey | Promoted to active roster | | | Before |
| 6/30/2008 | CIN | Loe | Demoted to reserve roster | | | Before |
| 6/30/2008 | LAA | Okajima | Demoted to reserve roster | | | Before |
| 6/30/2008 | LAA | Villarreal | Promoted to active roster | | | Before |
| 6/30/2008 | Mil | Buck | Demoted to reserve roster | | | Before |
| 6/30/2008 | Mil | Buehrle | Demoted to reserve roster | | | Before |
| 6/30/2008 | Mil | Burke | Promoted to active roster | | | Before |
| 6/30/2008 | Mil | Gomes | Demoted to reserve roster | | | Before |
| 6/30/2008 | Mil | Gomes | Promoted to active roster | | | Before |
| 6/30/2008 | Mil | Gorzelanny | Demoted to reserve roster | | | Before |
| 6/30/2008 | Mil | Hill | Promoted to active roster | | | Before |
| 6/30/2008 | Mil | Izturis | Demoted to reserve roster | | | Before |
| 6/30/2008 | Mil | Lannan | Promoted to active roster | | | Before |
| 6/30/2008 | Mil | Oswalt | Demoted to reserve roster | | | Before |
| 6/30/2008 | Mil | Oswalt | Promoted to active roster | | | Before |
| 6/30/2008 | Mil | Salazar | Promoted to active roster | | | Before |
| 6/30/2008 | Mil | Snyder | Demoted to reserve roster | | | Before |
| 6/30/2008 | Mil | Wilson | Promoted to active roster | | | Before |
| 6/30/2008 | NYY | Botts | Demoted to reserve roster | | | Before |
| 6/30/2008 | NYY | Davis | Promoted to active roster | | | Before |
| 6/30/2008 | NYY | Giambi | Demoted to reserve roster | | | Before |
| 6/30/2008 | NYY | Hirsh | Promoted to active roster | | | Before |
| 6/30/2008 | NYY | Paulino | Promoted to active roster | | | Before |
| 6/30/2008 | NYY | Taveras | Demoted to reserve roster | | | Before |
| 7/6/2008 | Atl | Colon | Demoted to reserve roster | | | Before |
| 7/6/2008 | Atl | Slowey | Promoted to active roster | | | Before |
| 7/6/2008 | CIN | Floyd | Demoted to reserve roster | | | Before |
| 7/6/2008 | CIN | Francisco | Promoted to active roster | | | Before |
| 7/6/2008 | CIN | Kennedy | Demoted to reserve roster | | | Before |
| 7/6/2008 | CIN | Thompson | Promoted to active roster | | | Before |
| 7/8/2008 | Mil | Buehrle | Promoted to active roster | | | Before |
| 7/8/2008 | Mil | Oswalt | Demoted to reserve roster | | | Before |
| 7/8/2008 | NYY | Paulino | Demoted to reserve roster | | | Before |
| 7/8/2008 | NYY | Ray | Promoted to active roster | | | Before |
| 7/14/2008 | Det | Broussard | Demoted to reserve roster | | | Before |
| 7/14/2008 | Det | Morales | Promoted to active roster | | | Before |
| 7/14/2008 | Mil | Gorzelanny | Promoted to active roster | | | Before |
| 7/14/2008 | Mil | Lannan | Demoted to reserve roster | | | Before |
| 7/14/2008 | Mil | Oswalt | Promoted to active roster | | | Before |
| 7/14/2008 | Mil | Redding | Demoted to reserve roster | | | Before |
| 7/14/2008 | SD | Bradley | Demoted to reserve roster | | | Before |
| 7/14/2008 | SD | Cruz | Promoted to active roster | | | Before |
| 7/14/2008 | SD | Delcarmen | Demoted to reserve roster | | | Before |
| 7/14/2008 | SD | Gonzalez | Promoted to active roster | | | Before |
| 7/16/2008 | Flo | Bourn | Promoted to active roster | | | Before |
| 7/16/2008 | Flo | Diaz | Demoted to reserve roster | | | Before |
| 7/22/2008 | ChA | Donnelly | Promoted to active roster | | | Before |
| 7/22/2008 | ChA | Herges | Demoted to reserve roster | | | Before |
| 7/22/2008 | CIN | Clark | Demoted to reserve roster | | | Before |
| 7/22/2008 | CIN | Dotel | Demoted to reserve roster | | | Before |
| 7/22/2008 | CIN | Floyd | Promoted to active roster | | | Before |
| 7/22/2008 | CIN | Laffey | Demoted to reserve roster | | | Before |
| 7/22/2008 | CIN | Loe | Promoted to active roster | | | Before |
| 7/22/2008 | CIN | Nippert | Promoted to active roster | | | Before |
| 7/22/2008 | KC | Abreu | Promoted to active roster | | | Before |
| 7/22/2008 | KC | Ankiel | Demoted to reserve roster | | | Before |
| 7/22/2008 | KC | McBride | Promoted to active roster | | | Before |
| 7/22/2008 | KC | Michaels | Demoted to reserve roster | | | Before |
| 7/22/2008 | LAA | Albers | Promoted to active roster | | | Before |
| 7/22/2008 | LAA | Hughes | Demoted to reserve roster | | | Before |
| 7/22/2008 | Tex | Bennett | Promoted to active roster | | | Before |
| 7/22/2008 | Tex | Lester | Demoted to reserve roster | | | Before |
| 7/22/2008 | Tex | Napoli | Demoted to reserve roster | | | Before |
| 7/22/2008 | Tex | VandenHurk | Promoted to active roster | | | Before |
| 7/22/2008 | Tor | Anderson | Demoted to reserve roster | | | Before |
| 7/22/2008 | Tor | Cabrera,F | Promoted to active roster | | | Before |
| 7/22/2008 | Tor | Everett | Promoted to active roster | | | Before |
| 7/22/2008 | Tor | Gross | Promoted to active roster | | | Before |
| 7/22/2008 | Tor | House | Promoted to active roster | | | Before |
| 7/22/2008 | Tor | Keppinger | Demoted to reserve roster | | | Before |
| 7/22/2008 | Tor | Kotsay | Promoted to active roster | | | Before |
| 7/22/2008 | Tor | Lewis | Demoted to reserve roster | | | Before |
| 7/22/2008 | Tor | Molina | Demoted to reserve roster | | | Before |
| 7/22/2008 | Tor | Podsednik | Demoted to reserve roster | | | Before |
| 7/24/2008 | KC | Duncan | Promoted to active roster | | | Before |
| 7/24/2008 | KC | Hannahan | Demoted to reserve roster | | | Before |
| 7/24/2008 | LAA | Okajima | Promoted to active roster | | | Before |
| 7/24/2008 | LAA | Villarreal | Demoted to reserve roster | | | Before |
| 7/30/2008 | ChA | Catalanotto | Promoted to active roster | | | Before |
| 7/30/2008 | ChA | Davies | Demoted to reserve roster | | | Before |
| 7/30/2008 | ChA | Petit | Promoted to active roster | | | Before |
| 7/30/2008 | ChA | Phillips | Demoted to reserve roster | | | Before |
| 8/1/2008 | Mil | Burke | Demoted to reserve roster | | | Before |
| 8/1/2008 | Mil | Snyder | Promoted to active roster | | | Before |
| 8/1/2008 | NYY | Davis | Demoted to reserve roster | | | Before |
| 8/1/2008 | NYY | Giambi | Demoted to reserve roster | | | Before |
| 8/1/2008 | NYY | Giambi | Promoted to active roster | | | Before |
| 8/1/2008 | NYY | Giambi | Promoted to active roster | | | Before |
| 8/1/2008 | NYY | Taveras | Promoted to active roster | | | Before |
| 8/1/2008 | NYY | Thorman | Demoted to reserve roster | | | Before |
| 8/1/2008 | NYY | Thorman | Promoted to active roster | | | Before |
| 8/1/2008 | NYY | Thorman | Demoted to reserve roster | | | Before |
| 8/9/2008 | Flo | Bourn | Demoted to reserve roster | | | Before |
| 8/9/2008 | Flo | Helms | Demoted to reserve roster | | | Before |
| 8/9/2008 | Flo | Helms | Promoted to active roster | | | Before |
| 8/9/2008 | Flo | Morales | Promoted to active roster | | | Before |
| 8/9/2008 | Mil | Buck | Promoted to active roster | | | Before |
| 8/9/2008 | Mil | O'Flaherty | Demoted to reserve roster | | | Before |
| 8/9/2008 | Mil | Redding | Promoted to active roster | | | Before |
| 8/9/2008 | Mil | Salazar | Demoted to reserve roster | | | Before |
| 8/9/2008 | Mil | Schumaker | Promoted to active roster | | | Before |
| 8/9/2008 | Mil | Wilson | Demoted to reserve roster | | | Before |
| 8/9/2008 | NYY | Giambi | Demoted to reserve roster | | | Before |
| 8/9/2008 | NYY | Lind | Demoted to reserve roster | | | Before |
| 8/9/2008 | NYY | Paulino | Promoted to active roster | | | Before |
| 8/9/2008 | NYY | Thorman | Promoted to active roster | | | Before |
| 8/15/2008 | ChA | Byrd | Demoted to reserve roster | | | Before |
| 8/15/2008 | ChA | Diaz | Promoted to active roster | | | Before |
| 8/15/2008 | ChA | Timlin | Demoted to reserve roster | | | Before |
| 8/15/2008 | ChA | Wood | Promoted to active roster | | | Before |
| 8/15/2008 | Mil | Hill | Demoted to reserve roster | | | Before |
| 8/15/2008 | Mil | Lannan | Promoted to active roster | | | Before |
| 8/15/2008 | Mil | O'Flaherty | Promoted to active roster | | | Before |
| 8/15/2008 | Mil | Redding | Demoted to reserve roster | | | Before |
| 8/15/2008 | NYY | Paulino | Demoted to reserve roster | | | Before |
| 8/15/2008 | NYY | Young | Promoted to active roster | | | Before |
| 8/17/2008 | Atl | Baker | Demoted to reserve roster | | | Before |
| 8/17/2008 | Atl | Gonzalez,Ed | Promoted to active roster | | | Before |
| 8/17/2008 | CIN | Kennedy | Promoted to active roster | | | Before |
| 8/17/2008 | CIN | Nippert | Demoted to reserve roster | | | Before |
| 8/25/2008 | CIN | Castillo | Promoted to active roster | | | Before |
| 8/25/2008 | CIN | Chavez | Promoted to active roster | | | Before |
| 8/25/2008 | CIN | Clark | Promoted to active roster | | | Before |
| 8/25/2008 | CIN | Dotel | Promoted to active roster | | | Before |
| 8/25/2008 | CIN | Laffey | Promoted to active roster | | | Before |
| 8/25/2008 | CIN | Nippert | Promoted to active roster | | | Before |
| 8/25/2008 | Flo | Bourn | Promoted to active roster | | | Before |
| 8/25/2008 | Flo | Chavez | Demoted to reserve roster | | | Before |
| 8/25/2008 | Flo | Devine | Promoted to active roster | | | Before |
| 8/25/2008 | Flo | Flores | Promoted to active roster | | | Before |
| 8/25/2008 | Flo | Lee | Promoted to active roster | | | Before |
| 8/25/2008 | Flo | Loewen | Promoted to active roster | | | Before |
| 8/25/2008 | Flo | Moss | Promoted to active roster | | | Before |
| 8/25/2008 | Flo | Raburn | Promoted to active roster | | | Before |
| 8/25/2008 | SD | Abercrombie | Promoted to active roster | | | Before |
| 8/25/2008 | SD | Cedeno | Promoted to active roster | | | Before |
| 8/25/2008 | SD | Delcarmen | Promoted to active roster | | | Before |
| 8/25/2008 | SD | Duchscherer | Promoted to active roster | | | Before |
| 8/25/2008 | SD | Duffy | Promoted to active roster | | | Before |
| 8/25/2008 | SD | Easley | Demoted to reserve roster | | | Before |
| 8/25/2008 | SD | Zobrist | Promoted to active roster | | | Before |
| 8/25/2008 | Tor | Betancourt | Demoted to reserve roster | | | Before |
| 8/25/2008 | Tor | Giles,M | Promoted to active roster | | | Before |
| 8/31/2008 | ChA | Byrd | Promoted to active roster | | | Before |
| 8/31/2008 | ChA | Davies | Promoted to active roster | | | Before |
| 8/31/2008 | ChA | Maxwell | Promoted to active roster | | | Before |
| 8/31/2008 | ChA | Timlin | Promoted to active roster | | | Before |
| 9/2/2008 | Atl | Thigpen | Promoted to active roster | | | Before |
| 9/2/2008 | Det | Baker | Promoted to active roster | | | Before |
| 9/2/2008 | Det | Bazardo | Promoted to active roster | | | Before |
| 9/2/2008 | Det | Broussard | Promoted to active roster | | | Before |
| 9/2/2008 | Det | Freel | Demoted to reserve roster | | | Before |
| 9/2/2008 | Det | Gomez | Promoted to active roster | | | Before |
| 9/2/2008 | Det | LaRoche | Promoted to active roster | | | Before |
| 9/2/2008 | Det | Mendoza | Promoted to active roster | | | Before |
| 9/2/2008 | Det | Morales | Demoted to reserve roster | | | Before |
| 9/2/2008 | Flo | Bourn | Promoted to active roster | | | Before |
| 9/2/2008 | Flo | Chavez | Demoted to reserve roster | | | Before |
| 9/2/2008 | Flo | Devine | Promoted to active roster | | | Before |
| 9/2/2008 | Flo | Flores | Promoted to active roster | | | Before |
| 9/2/2008 | Flo | Lee | Promoted to active roster | | | Before |
| 9/2/2008 | Flo | Loewen | Promoted to active roster | | | Before |
| 9/2/2008 | Flo | Moss | Promoted to active roster | | | Before |
| 9/2/2008 | Flo | Raburn | Promoted to active roster | | | Before |
| 9/2/2008 | KC | Duncan | Demoted to reserve roster | | | Before |
| 9/2/2008 | KC | Gonzalez | Promoted to active roster | | | Before |
| 9/2/2008 | KC | Guzman | Promoted to active roster | | | Before |
| 9/2/2008 | KC | Jacobs | Demoted to reserve roster | | | Before |
| 9/2/2008 | KC | Jones | Promoted to active roster | | | Before |
| 9/2/2008 | KC | Miles | Demoted to reserve roster | | | Before |
| 9/2/2008 | LAA | Albers | Demoted to reserve roster | | | Before |
| 9/2/2008 | LAA | Albers | Promoted to active roster | | | Before |
| 9/2/2008 | LAA | Cust | Demoted to reserve roster | | | Before |
| 9/2/2008 | LAA | Guzman | Demoted to reserve roster | | | Before |
| 9/2/2008 | LAA | Mirabelli | Demoted to reserve roster | | | Before |
| 9/2/2008 | LAA | Nolasco | Promoted to active roster | | | Before |
| 9/2/2008 | LAA | Patton | Promoted to active roster | | | Before |
| 9/2/2008 | LAA | Villarreal | Promoted to active roster | | | Before |
| 9/2/2008 | Mil | Izturis | Promoted to active roster | | | Before |
| 9/2/2008 | Mil | Lannan | Demoted to reserve roster | | | Before |
| 9/2/2008 | Mil | Misch | Promoted to active roster | | | Before |
| 9/2/2008 | Mil | Nunez | Promoted to active roster | | | Before |
| 9/2/2008 | NYY | Botts | Promoted to active roster | | | Before |
| 9/2/2008 | NYY | Chamberlain | Promoted to active roster | | | Before |
| 9/2/2008 | NYY | Giambi | Promoted to active roster | | | Before |
| 9/2/2008 | NYY | Lind | Promoted to active roster | | | Before |
| 9/2/2008 | NYY | Ramirez | Promoted to active roster | | | Before |
| 9/2/2008 | NYY | Young | Demoted to reserve roster | | | Before |
| 9/2/2008 | SD | Buscher | Promoted to active roster | | | Before |
| 9/2/2008 | SD | Grudzielanek | Demoted to reserve roster | | | Before |
| 9/2/2008 | SD | Murton | Demoted to reserve roster | | | Before |
| 9/2/2008 | SD | Wilson | Demoted to reserve roster | | | Before |
| 9/2/2008 | Tex | Coutlangus | Demoted to reserve roster | | | Before |
| 9/2/2008 | Tex | Coutlangus | Promoted to active roster | | | Before |
| 9/2/2008 | Tex | Francisco | Demoted to reserve roster | | | Before |
| 9/2/2008 | Tex | Francisco | Promoted to active roster | | | Before |
| 9/2/2008 | Tex | Garza | Demoted to reserve roster | | | Before |
| 9/2/2008 | Tex | Johnson | Demoted to reserve roster | | | Before |
| 9/2/2008 | Tex | Klesko | Demoted to reserve roster | | | Before |
| 9/2/2008 | Tex | Mora | Demoted to reserve roster | | | Before |
| 9/2/2008 | Tex | Rogers | Promoted to active roster | | | Before |
| 9/2/2008 | Tex | Saunders | Demoted to reserve roster | | | Before |
| 9/2/2008 | Tex | Stewart | Promoted to active roster | | | Before |
| 9/2/2008 | Tor | Renteria | Demoted to reserve roster | | | Before |
| 9/8/2008 | Atl | Bartlett | Demoted to reserve roster | | | Before |
| 9/8/2008 | Atl | Casilla | Promoted to active roster | | | Before |
| 9/8/2008 | Atl | Hart | Demoted to reserve roster | | | Before |
| 9/8/2008 | Atl | Ojeda | Demoted to reserve roster | | | Before |
| 9/8/2008 | Atl | Ojeda | Promoted to active roster | | | Before |
| 9/8/2008 | Atl | Snelling | Promoted to active roster | | | Before |
| 9/10/2008 | LAA | Milledge | Demoted to reserve roster | | | Before |
| 9/10/2008 | LAA | Mirabelli | Promoted to active roster | | | Before |
| 9/16/2008 | Atl | Colon | Promoted to active roster | | | Before |
| 9/16/2008 | Atl | Patterson | Promoted to active roster | | | Before |
| 9/16/2008 | Atl | Slowey | Demoted to reserve roster | | | Before |
| 9/18/2008 | LAA | Albers | Demoted to reserve roster | | | Before |
| 9/18/2008 | LAA | Cust | Promoted to active roster | | | Before |
| 9/18/2008 | LAA | Guzman | Promoted to active roster | | | Before |
| 9/18/2008 | LAA | Milledge | Promoted to active roster | | | Before |
| 9/18/2008 | LAA | Nolasco | Demoted to reserve roster | | | Before |
| 9/18/2008 | LAA | Patton | Demoted to reserve roster | | | Before |
| 9/18/2008 | Mil | Hopper | Demoted to reserve roster | | | Before |
| 9/18/2008 | Mil | O'Flaherty | Demoted to reserve roster | | | Before |
| 9/18/2008 | Mil | Wilson | Promoted to active roster | | | Before |
| 9/24/2008 | Atl | Baker | Promoted to active roster | | | Before |
| 9/24/2008 | Atl | Bartlett | Promoted to active roster | | | Before |
| 9/24/2008 | Atl | Callaspo | Demoted to reserve roster | | | Before |
| 9/24/2008 | Atl | Casilla | Demoted to reserve roster | | | Before |
| 9/24/2008 | Atl | Casilla | Promoted to active roster | | | Before |
| 9/24/2008 | Atl | Colon | Demoted to reserve roster | | | Before |
| 9/24/2008 | Atl | Ellsbury | Promoted to active roster | | | Before |
| 9/24/2008 | Atl | Gonzalez,Ed | Demoted to reserve roster | | | Before |
| 9/24/2008 | Atl | Hart | Promoted to active roster | | | Before |
| 9/24/2008 | Atl | Ojeda | Promoted to active roster | | | Before |
| 9/24/2008 | Atl | Patterson | Demoted to reserve roster | | | Before |
| 9/24/2008 | Atl | Slowey | Promoted to active roster | | | Before |
| 9/24/2008 | Atl | Smith | Demoted to reserve roster | | | Before |
| 9/24/2008 | Atl | Smith | Promoted to active roster | | | Before |
| 9/24/2008 | Atl | Snelling | Demoted to reserve roster | | | Before |
| 9/24/2008 | Atl | Thigpen | Demoted to reserve roster | | | Before |
| 9/24/2008 | Atl | Valentin | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Byrd | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Byrd | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Catalanotto | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Catalanotto | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Davies | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Davies | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Diaz | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Donnelly | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Donnelly | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Duncan | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Duncan | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Fogg | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Fogg | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Graffanino | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Graffanino | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Greene | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Greene | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Herges | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Herges | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Herges | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Herges | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Laird | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Laird | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Logan | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Logan | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Marquis | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Marquis | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Maxwell | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Mench | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Mench | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Miller | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Miller | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Pena | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Pena | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Perez | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Perez | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Petit | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Pierre | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Pierre | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Rivera | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Rivera | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Timlin | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Timlin | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Utley | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Utley | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Valentin | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Valentin | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Wickman | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Wickman | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Wigginton | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Wigginton | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Williams | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Williams | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Winn | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Winn | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Wood | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Wood | Promoted to active roster | | | Before |
| 9/24/2008 | ChA | Zimmerman | Demoted to reserve roster | | | Before |
| 9/24/2008 | ChA | Zimmerman | Promoted to active roster | | | Before |
| 9/24/2008 | SD | Abercrombie | Demoted to reserve roster | | | Before |
| 9/24/2008 | SD | Bradley | Promoted to active roster | | | Before |
| 9/24/2008 | SD | Buscher | Demoted to reserve roster | | | Before |
| 9/24/2008 | SD | Cedeno | Demoted to reserve roster | | | Before |
| 9/24/2008 | SD | Cruz | Demoted to reserve roster | | | Before |
| 9/24/2008 | SD | Duchscherer | Demoted to reserve roster | | | Before |
| 9/24/2008 | SD | Duffy | Demoted to reserve roster | | | Before |
| 9/24/2008 | SD | Easley | Promoted to active roster | | | Before |
| 9/24/2008 | SD | Gathright | Demoted to reserve roster | | | Before |
| 9/24/2008 | SD | Gathright | Promoted to active roster | | | Before |
| 9/24/2008 | SD | Grudzielanek | Demoted to reserve roster | | | Before |
| 9/24/2008 | SD | Grudzielanek | Promoted to active roster | | | Before |
| 9/24/2008 | SD | Grudzielanek | Promoted to active roster | | | Before |
| 9/24/2008 | SD | Harris | Demoted to reserve roster | | | Before |
| 9/24/2008 | SD | Harris | Promoted to active roster | | | Before |
| 9/24/2008 | SD | Izturis | Demoted to reserve roster | | | Before |
| 9/24/2008 | SD | Izturis | Promoted to active roster | | | Before |
| 9/24/2008 | SD | Murton | Demoted to reserve roster | | | Before |
| 9/24/2008 | SD | Murton | Promoted to active roster | | | Before |
| 9/24/2008 | SD | Murton | Promoted to active roster | | | Before |
| 9/24/2008 | SD | Tyner | Demoted to reserve roster | | | Before |
| 9/24/2008 | SD | Wilson | Promoted to active roster | | | Before |
| 9/24/2008 | SD | Young | Demoted to reserve roster | | | Before |
| 9/24/2008 | SD | Young | Promoted to active roster | | | Before |
| 9/24/2008 | SD | Zobrist | Demoted to reserve roster | | | Before |